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Cyclobenzaprine: Side Effects, dosage, uses, and more

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Cyclobenzaprine: Side Effects, dosage, uses, and more

Many inpatient rehab centers offer a full day of group therapy sessions in a setting in which medications can also be prescribed and monitored. Outpatient treatment approaches vary in length but often consist of a half-day group therapy program in which any necessary medications are managed by an outside healthcare provider. This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Check with your doctor before taking any of the above while you are using this medicine. Cyclobenzaprine usually begins working about one hourafter it is ingested, relaxing muscles and relieving muscle spasms. Formulations include immediate-release and extended-release.

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As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively.

Avoid driving or hazardous activity until you know how cyclobenzaprine will affect you. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. It is unknown if this medication passes into breast milk. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. There is 1 alcohol/food interaction with Flexeril (cyclobenzaprine).

More About Drugs and Medications

The combination of Cyclobenzaprine and alcohol, weed, or Ibuprofen may increase the risk of side effects, just not as much as Tramadol does. Before combining and taking any of them, one must assess the medical risks that come with them to ensure that necessary actions are taken as needed. Over 375 drugs are known to interact with Cyclobenzaprine, with over 77% of them being moderate. That said, over 20% of them are known to cause major drug interactions, while just a little over 1% of them cause minor drug interactions. Alcohol, for instance, moderately interacts when mixed with Flexeril, and the same goes with weed.

  • This medication has been prescribed for your current condition only.
  • The incidence of drowsiness, the most frequent adverse reaction, was similar with both drugs.
  • It is often used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.
  • It works by blocking nerve impulses (or pain sensations) that are sent to your brain.
  • Individuals should not use these drugs together if they are not under the supervision of a physician.

This page will go over its side effects, drug interactions, and treatment for misuse. Concomitant use of monoamine oxidase (MAO) inhibitors or within 14 days after their discontinuation. Hyperpyretic crisis seizures, and deaths have occurred in patients receiving cyclobenzaprine (or structurally similar tricyclic can flexeril make you sleepy antidepressants) concomitantly with MAO inhibitor drugs. These patients are generally more susceptible to drugs with potentially sedating effects, including cyclobenzaprine. FLEXERIL should be used with caution in subjects with mild hepatic impairment starting with a 5 mg dose and titrating slowly upward.


Taking the two drugs together can increase your risk of side effects and the chances of a cyclobenzaprine overdose. Cyclobenzaprine comes as a tablet and an extended-release capsule to take by mouth. The tablet is usually taken with or without food three times a day. The extended-release capsule is usually taken with or without food once a day. Do not take this drug for more than 3 weeks without talking to your doctor.

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Cyclobenzaprine is a skeletal muscle relaxant that works on the brainstem to treat muscle spasms of local origin. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Do not use Flexeril if you have taken an MAO inhibitor in the past 14 days. In the US – Call your doctor for medical advice about side effects.

Our Flexeril (cyclobenzaprine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Mixing marijuana with the antihistamine hydroxyzine can potentially cause unwanted interactions and shouldn’t be combined. At our Palm Springs drug rehab, there is always a highly trained professional who is available to speak to you and answer any questions that you may have. After the realization that you have an addiction, receiving professional help is the very next step. We welcome you to your journey to recovery with open arms. For this reason, if you take it regularly, you should avoid alcohol.

Minor Interactions

The plasma concentration of cyclobenzaprine is increased in the elderly (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Elderly). The elderly may also be more at risk for CNS adverse events such as hallucinations and confusion, cardiac events resulting in falls or other sequelae, drug-drug and drug-disease interactions. For these reasons, in the elderly, cyclobenzaprine should be used only if clearly needed. In such patients FLEXERIL should be initiated with a 5 mg dose and titrated slowly upward. Serotonin syndrome is an often severe, potentially life-threatening adverse drug reaction that may result from inadvertent interactions between drugs with serotoninergic activity (1).

Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. Talk with your doctor about other drug options that may work for you. As with all medications, the costs of cyclobenzaprine can vary. Calls to our general hotline may be answered by private treatment providers. We may be paid a fee for marketing or advertising by organizations that can assist with treating people with substance use disorders.